Cellular and Molecular Life Sciences

, Volume 70, Issue 8, pp 1381–1392

Chromosomal translocations among the healthy human population: implications in oncogenesis

Review

DOI: 10.1007/s00018-012-1135-x

Cite this article as:
Nambiar, M. & Raghavan, S.C. Cell. Mol. Life Sci. (2013) 70: 1381. doi:10.1007/s00018-012-1135-x

Abstract

Chromosomal translocations are characteristic features of many cancers, especially lymphoma and leukemia. However, recent reports suggest that many chromosomal translocations can be found in healthy individuals, although the significance of this observation is still not clear. In this review, we summarize recent studies on chromosomal translocations in healthy individuals carried out in different geographical areas of the world and discuss the relevance of the observation with respect to oncogenesis.

Keywords

Leukemia Lymphoma Neoplasia Carcinoma Sarcoma Genomic instability V(D)J recombination 

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  1. 1.Department of BiochemistryIndian Institute of ScienceBangaloreIndia

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