Cellular and Molecular Life Sciences

, Volume 69, Issue 21, pp 3533–3541 | Cite as

MicroRNA-29 in the adaptive immune system: setting the threshold

  • Adrian Liston
  • Aikaterini S. Papadopoulou
  • Dina Danso-Abeam
  • James Dooley
Multi-author review

Abstract

Recent research into the role of microRNA (miR) in the immune system has identified the miR-29 family as critical regulators of key processes in adaptive immunity. The miR-29 family consists of four members with shared regulatory capacity, namely miR-29a, miR-29b-1, miR-29b-2 and miR-29c. Being expressed in both T and B cells, as well as the main accessory cell types of thymic epithelium and dendritic cells, the miR-29 family has been identified as a putative regulator of immunity due to the predicted suppression of key immunological pathways. The generation of a series of in vivo molecular tools targeting the miR-29 family has identified the critical role of these miR in setting the molecular threshold for three central events in adaptive immunity: (1) control over thymic production of T cells by modulating the threshold for infection-associated thymic involution, (2) creating a neutral threshold for T cell polarization following activation, and (3) setting the threshold for B cell oncogenic transformation. These results identify the miR-29 family as potent immune modulators which have already been exploited through the evolution of a viral mimic and could potentially be exploited further for therapeutic intervention.

Keywords

MicroRNA Thymus T cells B cells Immunology Leukemia 

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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Adrian Liston
    • 1
  • Aikaterini S. Papadopoulou
    • 2
  • Dina Danso-Abeam
    • 1
  • James Dooley
    • 1
  1. 1.Autoimmune Genetics LaboratoryVIB and University of LeuvenLeuvenBelgium
  2. 2.Center for Human GeneticsVIB and University of LeuvenLeuvenBelgium

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