Cellular and Molecular Life Sciences

, Volume 69, Issue 19, pp 3285–3299

Induced pluripotent stem cells for cardiac repair

Review

Abstract

Myocardial stem cell therapies are emerging as novel therapeutic paradigms for myocardial repair, but are hampered by the lack of sources for autologous human cardiomyocytes. An exciting development in the field of cardiovascular regenerative medicine is the ability to reprogram adult somatic cells into pluripotent stem cell lines (induced pluripotent stem cells, iPSCs) and to coax their differentiation into functional cardiomyocytes. This technology holds great promise for the emerging disciplines of personalized and regenerative medicine, because of the ability to derive patient-specific iPSCs that could potentially elude the immune system. The current review describes the latest techniques of generating iPSCs as well as the methods used to direct their differentiation towards the cardiac lineage. We then detail the unique potential as well as the possible hurdles on the road to clinical utilizing of the iPSCs derived cardiomyocytes in the emerging field of cardiovascular regenerative medicine.

Keywords

Induced pluripotent stem cells Cardiomyocytes Disease modeling Drug screening Cell therapy Myocardial repair Heart diseases 

Abbreviations

CPCs

Cardiac progenitor cells

EBs

Embryoid bodies

ESCs

Embryonic stem cells

hESCs

Human embryonic stem cells

hiPSCs

Human-induced pluripotent stem cells

hiPSCs-CMs

Human-induced pluripotent stem cells-derived cardiomyocytes

hPSCs

Human pluripotent stem cells

iPSCs

Induced pluripotent stem cells

miPSCs

Murine-induced pluripotent stem cells

miRNAs

MicroRNAs

MSCs

Mesenchymal stem cells

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  1. 1.The Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Rappaport Faculty of Medicine and Research Institute, Technion’s Faculty of MedicineTechnion–Israel Institute of TechnologyHaifaIsrael
  2. 2.The Biotechnology Interdisciplinary UnitTechnion–Israel Institute of TechnologyHaifaIsrael

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