Cellular and Molecular Life Sciences

, Volume 70, Issue 2, pp 239–255 | Cite as

Prevention or acceleration of type 1 diabetes by viruses

  • Liana Ghazarian
  • Julien Diana
  • Yannick Simoni
  • Lucie Beaudoin
  • Agnès Lehuen


Type 1 diabetes is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Even though extensive scientific research has yielded important insights into the immune mechanisms involved in pancreatic β-cell destruction, little is known about the events that trigger the autoimmune process. Recent epidemiological and experimental data suggest that environmental factors are involved in this process. In this review, we discuss the role of viruses as an environmental factor on the development of type 1 diabetes, and the immune mechanisms by which they can trigger or protect against this pathology.


Diabetes Environment Virus Coxsackievirus 



We apologize to all the authors whose work we could not cite owing to space constrictions. This work was supported by funds from the Institut National de la Santé et de la Recherche Médicale and the Centre National pour la Recherche Scientifique, grant from ANR-09-GENO-023 and LABEX INFLAMEX to AL. Liana Ghazarian and Yannick Simoni were supported by doctoral fellowships from the Ministère de l'Education Nationale et de la Recherche et Technique and from Région Île-de-France.

Competing interests statement

The authors declare no competing financial interests.


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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  1. 1.Hôpital Saint Vincent de Paul/CochinParisFrance

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