Cellular and Molecular Life Sciences

, Volume 69, Issue 14, pp 2435–2442

Targeting NADPH oxidases for the treatment of cancer and inflammation

Multi-author review


NADPH oxidases are a family of oxidases that utilize molecular oxygen to generate hydrogen peroxide and superoxide, thus indicating physiological functions of these highly reactive and short-lived species. The regulation of these NADPH oxidases (nox) enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. While the complexity of the nox family (Nox1–5, Duox1, 2) is daunting, the complexity also allows for targeting of NADPH oxidases in disease states. In this review, we discuss which inflammatory and malignant disorders can be targeted by nox inhibitors, as well as clinical experience in the use of such inhibitors.


NADPH oxidase Lymphoma Melanoma Hemangioma Wilms tumor 1 Triphenylmethanes Fulvenes 

Copyright information

© Springer Basel AG (outside the USA) 2012

Authors and Affiliations

  1. 1.Department of DermatologyEmory University School of MedicineAtlantaUSA
  2. 2.Atlanta Veterans Administration Medical CenterAtlantaUSA

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