Cellular and Molecular Life Sciences

, Volume 69, Issue 24, pp 4079–4092 | Cite as

Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein

  • Magdolna Szántó
  • Attila Brunyánszki
  • Borbála Kiss
  • Lilla Nagy
  • Pál Gergely
  • László Virág
  • Péter Bai
Review

Abstract

Poly(ADP-ribose) polymerase (PARP)-2 is a nuclear enzyme that belongs to the PARP family and PARP-2 is responsible for 5–15 % of total cellular PARP activity. PARP-2 was originally described in connection to DNA repair and in physiological and pathophysiological processes associated with genome maintenance (e.g., centromere and telomere protection, spermiogenesis, thymopoiesis, azoospermia, and tumorigenesis). Recent reports have identified important rearrangements in gene expression upon the knockout of PARP-2. Such rearrangements heavily impact inflammation and metabolism. Metabolic effects are mediated through modifying PPARγ and SIRT1 function. Altered gene expression gives rise to a complex phenotype characterized primarily by enhanced mitochondrial activity that results both in beneficial (loss of fat, enhanced insulin sensitivity) and in disadvantageous (pancreatic beta cell hypofunction upon high fat feeding) consequences. Enhanced mitochondrial biogenesis provides protection in oxidative stress-related diseases. Hereby, we review the recent developments in PARP-2 research with special attention to the involvement of PARP-2 in transcriptional and metabolic regulation.

Keywords

PARP-2 ARTD2 SIRT1 DNA repair Differentiation Metabolism Mitochondria 

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    (2012) LOC505828 poly[ADP-ribose] polymerase 2-like [Bos taurus] NCBI Pubmed. http://www.ncbi.nlm.nih.gov/gene/505828. Accessed 17 April 2012
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    (2012) PARP2 poly(ADP-ribose) polymerase 2 [Callithrix jacchus] NCBI Pubmed. http://www.ncbi.nlm.nih.gov/gene/100388484. Accessed 17 April 2012
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    (2012) PARP2 poly(ADP-ribose) polymerase 2 [Canis lupus familiaris] NCBI Pubmed. http://www.ncbi.nlm.nih.gov/gene/475392. Accessed 17 April 2012
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    (2012) PARP2 poly(ADP-ribose) polymerase 2 [Equus caballus] NCBI Pubmed. http://www.ncbi.nlm.nih.gov/gene/100072572. Accessed 17 April 2012
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    (2012) PARP2 poly(ADP-ribose) polymerase 2 [Loxodonta africana] NCBI Pubmed. http://www.ncbi.nlm.nih.gov/gene/100661865. Accessed 17 April 2012
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    (2012) PARP2 poly(ADP-ribose) polymerase 2 [Macaca mulatta] NCBI Pubmed. http://www.ncbi.nlm.nih.gov/gene/701955. Accessed 17 April 2012
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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Magdolna Szántó
    • 1
  • Attila Brunyánszki
    • 1
  • Borbála Kiss
    • 2
  • Lilla Nagy
    • 1
  • Pál Gergely
    • 1
  • László Virág
    • 1
  • Péter Bai
    • 1
  1. 1.Medical and Health Science Center, MHSC, Department of Medical ChemistryUniversity of DebrecenDebrecenHungary
  2. 2.Medical and Health Science Center, Department of DermatologyUniversity of DebrecenDebrecenHungary

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