Cellular and Molecular Life Sciences

, Volume 69, Issue 10, pp 1565–1575

TCR signaling requirements for activating T cells and for generating memory

  • Dietmar Zehn
  • Carolyn King
  • Michael J. Bevan
  • Ed Palmer
Multi-author review

DOI: 10.1007/s00018-012-0965-x

Cite this article as:
Zehn, D., King, C., Bevan, M.J. et al. Cell. Mol. Life Sci. (2012) 69: 1565. doi:10.1007/s00018-012-0965-x

Abstract

Over the last two decades the molecular and cellular mechanisms underlying T cell activation, expansion, differentiation, and memory formation have been intensively investigated. These studies revealed that the generation of memory T cells is critically impacted by a number of factors, including the magnitude of the inflammatory response and cytokine production, the type of dendritic cell [DC] that presents the pathogen derived antigen, their maturation status, and the concomitant provision of costimulation. Nevertheless, the primary stimulus leading to T cell activation is generated through the T cell receptor [TCR] following its engagement with a peptide MHC ligand [pMHC]. The purpose of this review is to highlight classical and recent findings on how antigen recognition, the degree of TCR stimulation, and intracellular signal transduction pathways impact the formation of effector and memory T cells.

Keywords

T cell differentiation Effector and memory T cells T cell signaling Strength of the TCR signal 

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Dietmar Zehn
    • 1
  • Carolyn King
    • 2
  • Michael J. Bevan
    • 3
  • Ed Palmer
    • 2
  1. 1.Division of Immunology and AllergyCentre Hospitalier Universitaire Vaudois and Swiss Vaccine Research InstituteEpalingesSwitzerland
  2. 2.Laboratory of Transplantation Immunology, Department of BiomedicineUniversity Hospital BaselBaselSwitzerland
  3. 3.Department of ImmunologyUniversity of WashingtonSeattleUSA

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