Cellular and Molecular Life Sciences

, Volume 69, Issue 16, pp 2635–2656 | Cite as

Regenerating functional heart tissue for myocardial repair



Heart disease is one of the leading causes of death worldwide and the number of patients with the disease is likely to grow with the continual decline in health for most of the developed world. Heart transplantation is one of the only treatment options for heart failure due to an acute myocardial infarction, but limited donor supply and organ rejection limit its widespread use. Cellular cardiomyoplasty, or cellular implantation, combined with various tissue-engineering methods aims to regenerate functional heart tissue. This review highlights the numerous cell sources that have been used to regenerate the heart as well as cover the wide range of tissue-engineering strategies that have been devised to optimize the delivery of these cells. It will probably be a long time before an effective regenerative therapy can make a serious impact at the bedside.


Myocardial repair Tissue engineering Tissue regeneration Heart tissue Cardiac tissue Heart repair Heart regeneration 



Coronary artery bypass graft


Embryonic stem cells


Hematopoietic stem cells


Human embryonic stem cell-derived cardiomyocytes


Induced pluripotent stem cells


Islet 1 transcription factor


Left anterior descending


Left ventricular assist device


Left ventricular end-diastolic volume


Left ventricular ejection fraction


Myocardial infarct


Poly ε-caprolactone


Polyglycolic acid




Polylactic acid


Stem cell antigen 1


T-box transcription factor 18




Tetramethylrhodamine methyl ester perchlorate


Wilm’s tumor 1


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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Andre Alcon
    • 1
  • Esra Cagavi Bozkulak
    • 2
  • Yibing Qyang
    • 2
  1. 1.Yale University School of MedicineYale UniversityNew HavenUSA
  2. 2.Section of Cardiovascular Medicine, Department of Internal Medicine, Yale Cardiovascular Research Center, Yale Stem Cell Center, Yale School of MedicineYale UniversityNew HavenUSA

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