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Cellular and Molecular Life Sciences

, Volume 69, Issue 6, pp 915–930 | Cite as

Regulation of cholesterol homeostasis

  • Leigh Goedeke
  • Carlos Fernández-Hernando
Review

Abstract

Cholesterol homeostasis is among the most intensely regulated processes in biology. Since its isolation from gallstones at the time of the French Revolution, cholesterol has been extensively studied. Insufficient or excessive cellular cholesterol results in pathological processes including atherosclerosis and metabolic syndrome. Mammalian cells obtain cholesterol from the circulation in the form of plasma lipoproteins or intracellularly, through the synthesis of cholesterol from acetyl coenzyme A (acetyl-CoA). This process is tightly regulated at multiple levels. In this review, we provide an overview of the multiple mechanisms by which cellular cholesterol metabolism is regulated. We also discuss the recent advances in the post-transcriptional regulation of cholesterol homeostasis, including the role of small non-coding RNAs (microRNAs). These novel findings may open new avenues for the treatment of dyslipidemias and cardiovascular diseases.

Keywords

Cholesterol homeostasis SREBP HDL MicroRNAs 

Notes

Acknowledgments

The authors would like to thank Dr. Yajaira Suárez for her helpful comments and stimulating discussions. C.F.-H. laboratory is supported by grants from the National Institute of Health (R01HL106063 and R01HL107953). We apologize to those whose work could not be cited.

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© Springer Basel AG 2011

Authors and Affiliations

  1. 1.Departments of Medicine and Cell Biology, Leon H. Charney Division of CardiologyNew York University School of MedicineNew YorkUSA

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