Cellular and Molecular Life Sciences

, Volume 69, Issue 7, pp 1035–1047

Structural and functional relationships between photoreceptor tetraspanins and other superfamily members

  • Shannon M. Conley
  • Michael W. Stuck
  • Muna I. Naash
Review

DOI: 10.1007/s00018-011-0736-0

Cite this article as:
Conley, S.M., Stuck, M.W. & Naash, M.I. Cell. Mol. Life Sci. (2012) 69: 1035. doi:10.1007/s00018-011-0736-0

Abstract

The two primary photoreceptor-specific tetraspanins are retinal degeneration slow (RDS) and rod outer segment membrane protein-1 (ROM-1). These proteins associate together to form different complexes necessary for the proper structure of the photoreceptor outer segment rim region. Mutations in RDS cause blinding retinal degenerative disease in both rods and cones by mechanisms that remain unknown. Tetraspanins are implicated in a variety of cellular processes and exert their function via the formation of tetraspanin-enriched microdomains. This review focuses on correlations between RDS and other members of the tetraspanin superfamily, particularly emphasizing protein structure, complex assembly, and post-translational modifications, with the goal of furthering our understanding of the structural and functional role of RDS and ROM-1 in outer segment morphogenesis and maintenance, and our understanding of the pathogenesis associated with RDS and ROM-1 mutations.

Keywords

RDS ROM1 Tetraspanin Eye 

Copyright information

© Springer Basel AG 2011

Authors and Affiliations

  • Shannon M. Conley
    • 1
  • Michael W. Stuck
    • 1
  • Muna I. Naash
    • 1
  1. 1.Department of Cell BiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA

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