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Cellular and Molecular Life Sciences

, Volume 68, Issue 15, pp 2493–2498 | Cite as

Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest

  • James D. Smith
  • Maria H. Meehan
  • John Crean
  • Amanda McCann
Visions and Reflections

Abstract

Alpha-T-Catenin (CTNNA3) is a key protein of the adherens junctional complex in epithelial cells playing a crucial role in cellular adherence. What makes this gene particularly interesting is that it is located within a common fragile site, is epigenetically regulated, is transcribed through multiple promoters, and generates a variety of alternate transcripts. Finally, CTNNA3 has a nested gene (LRTMM3) embedded within its genomic context transcribed in the opposite direction. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease.

Keywords

CTNNA3 LRTMM3 Alpha-T-catenin Adherens junction Nested gene 

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Copyright information

© Springer Basel AG 2011

Authors and Affiliations

  • James D. Smith
    • 1
    • 2
  • Maria H. Meehan
    • 1
    • 2
  • John Crean
    • 1
    • 3
  • Amanda McCann
    • 1
    • 2
  1. 1.UCD Conway Institute of Biomolecular and Biomedical ResearchUniversity College Dublin (UCD)Dublin 4Ireland
  2. 2.UCD School of Medicine and Medical Science (UCD SMMS)University College Dublin (UCD)Dublin 4Ireland
  3. 3.UCD School of Biomolecular and Biomedical Sciences (UCD SBBS)University College Dublin (UCD)Dublin 4Ireland

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