Cellular and Molecular Life Sciences

, Volume 68, Issue 11, pp 1871–1881 | Cite as

Matrix control of scarring

Review

Abstract

Repair of wounds usually results in restoration of organ function, even if suboptimal. However, in a minority of situations, the healing process leads to significant scarring that hampers homeostasis and leaves the tissue compromised. This scar is characterized by an excess of matrix deposition that remains poorly organized and weakened. While we know much of the early stages of the repair process, the transition to wound resolution that limits scar formation is poorly understood. This is particularly true of the inducers of scar formation. Here, we present a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations.

Keywords

Fibrosis ECM CXCR3 Tenascin C Fibronectin 

Notes

Acknowledgments

These studies were supported by grants from the National Institute of General Medical Science of the National Institutes of Health (USA) (GM063569). Services in kind were provided by the Pittsburgh VA Medical Center.

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Copyright information

© Springer Basel AG 2011

Authors and Affiliations

  • Cecelia C. Yates
    • 1
  • Richard Bodnar
    • 1
    • 2
  • Alan Wells
    • 1
    • 2
  1. 1.Department of PathologyUniversity of PittsburghPittsburghUSA
  2. 2.Pittsburgh VAMCPittsburghUSA

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