Cellular and Molecular Life Sciences

, Volume 68, Issue 10, pp 1645–1656 | Cite as

Injury-induced neurogenesis in the mammalian forebrain



It has been accepted that new neurons are added to the olfactory bulb and the hippocampal dentate gyrus throughout life in the healthy adult mammalian brain. Recent studies have clarified that brain insult raises the proliferation of neural stem cells/neural progenitor cells existing in the subventricular zone and the subgranular zone, which become sources of new neurons for the olfactory bulb and the dentate gyrus, respectively. Interestingly, convincing data has shown that brain insult invokes neurogenesis in various brain regions, such as the hippocampal cornu ammonis region, striatum, and cortex. These reports suggest that neural stem cells/neural progenitor cells, which can be activated by brain injury, might be broadly located in the adult brain or that new neurons may migrate widely from the neurogenic regions. This review focuses on brain insult-induced neurogenesis in the mammalian forebrain, especially in the neocortex.


Insult Ischemia Neurogenesis Stem cells Progenitor cell Proliferation 





Cornu ammonis


Layer 1 inhibitory neuron progenitor


Medial ganglionic eminence


Neural stem cell


Neural progenitor cell


Subgranular zone


Subventricular zone



I thank Dr. Greta Anderson for critical reading of the manuscript. This work was supported by the Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Young Scientists (B), 21700384.


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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  1. 1.Division of Systems Medical Science, Institute for Comprehensive Medical ScienceFujita Health UniversityToyoakeJapan

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