Cellular and Molecular Life Sciences

, Volume 68, Issue 4, pp 587–597 | Cite as

Aging and TOR: interwoven in the fabric of life

Review

Abstract

Longstanding results with calorie and growth factor restriction plus recent results with the first interventional drug suggest that retarding the pace of aging to improve the quality of life of older people is at hand. The biological system targeted by these approaches is the target of rapamycin (TOR), which is central for cellular responses to a variety of stimuli including stressors, growth factors, and nutrients and energy states. That the life-extending response to reducing its activity is highly conserved from yeast to mammals is consistent with the evolution of aging as a strategy to preserve reproductive potential of young cells and animals.

Keywords

mTOR Rapamycin Healthy lifespan Growth factor restriction Caloric restriction 

Notes

Acknowledgments

Numerous discussions with the experts in aging research in the Institute of Biotechnology and Barshop Institute for Longevity and Aging Studies are gratefully acknowledged. I would also like to thank ITP investigators, Randy Strong, Rich Miller, David Harrison and Nancy Nadon for their knowledge and expertise in conducting aging studies, and for being wonderful colleagues in this ongoing adventure. Work in the author’s laboratory is supported by a Grand Opportunity grant from the NIH and by the Glenn Foundation. Finally, I would like to thank the anonymous reviewers for very helpful and insightful suggestions for improving the paper.

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© Springer Basel AG 2010

Authors and Affiliations

  1. 1.Department of Molecular Medicine, Institute of BiotechnologyUniversity of Texas Health Science Center San AntonioSan AntonioUSA

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