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Cellular and Molecular Life Sciences

, Volume 67, Issue 19, pp 3275–3285 | Cite as

Sexual reproduction in the Candida clade: cryptic cycles, diverse mechanisms, and alternative functions

  • Kevin Alby
  • Richard J. Bennett
Review

Abstract

To have sex, or not to have sex, is a question posed by many microorganisms. In favor of a sexual lifestyle is the associated rearrangement of genetic material that confers potential fitness advantages, including resistance to antimicrobial agents. The asexual lifestyle also has benefits, as it preserves complex combinations of genes that may be optimal for pathogenesis. For this reason, it was thought that several pathogenic fungi favored strictly asexual modes of reproduction. Recent approaches using genome sequencing, population analysis, and experimental techniques have now revised this simplistic picture. It is now apparent that many pathogenic fungi have retained the ability to undergo sexual reproduction, although reproduction is primarily clonal in origin. In this review, we highlight the current understanding of sexual programs in the Candida clade of species. We also examine evidence that sexual-related processes can be used for functions in addition to mating and recombination in these organisms.

Keywords

Recombination Biofilm Pheromone Adhesion Mating Fitness 

Notes

Acknowledgments

Work in the author’s laboratory was supported by a PATH award from the Burroughs Wellcome Fund (RJB) as well as the NIH (R21AI081560 to RJB and F31DE019752 to KA). We thank Racquel Sherwood for comments on the manuscript.

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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  1. 1.Department of Molecular Microbiology and ImmunologyBrown UniversityProvidenceUSA

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