Cellular and Molecular Life Sciences

, Volume 67, Issue 16, pp 2679–2683 | Cite as

Do we already know how spectrin attracts ankyrin?

  • Aleksander Czogalla
  • Aleksander F. SikorskiEmail author
Visions & Reflections (Minireview)


The interaction of ankyrin and spectrin yields the major anchor between the membrane skeleton and the lipid bilayer. It is critical for red cell deformability and stability, and it is also involved in the cellular localization of several proteins, in cell differentiation, and in neuron activity. Therefore, its nature is of great interest, and recently, several researchers have had varying degrees of success in elucidating the structural basis of ankyrin–spectrin recognition. In this short paper, we briefly summarize the data obtained and compare the resulting conclusions.


Spectrin Ankyrin Membrane skeleton Protein structure Protein–protein interactions 



This publication was possible thanks to the financial support of the Foundation for Polish Science. We acknowledge Mr. Derek Handley for proofreading this manuscript.


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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Aleksander Czogalla
    • 1
    • 2
  • Aleksander F. Sikorski
    • 2
    • 3
    Email author
  1. 1.Research and Development Centre Novasome Sp. z o.o.WrocławPoland
  2. 2.Faculty of BiotechnologyUniversity of WrocławWrocławPoland
  3. 3.Academic Centre for the Biotechnology of Lipid AggregatesWrocławPoland

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