Cellular and Molecular Life Sciences

, Volume 67, Issue 17, pp 2863–2878 | Cite as

The persistence of T cell memory

  • Mark A. Daniels
  • Emma TeixeiroEmail author


T cell memory is a crucial feature of the adaptive immune system in the defense against pathogens. During the last years, numerous studies have focused their efforts on uncovering the signals, inflammatory cues, and extracellular factors that support memory differentiation. This research is beginning to decipher the complex gene network that controls memory programming. However, how the different signals, that a T cell receives during the process of differentiation, interplay to trigger memory programming is still poorly defined. In this review, we focus on the most recent advances in the field and discuss how T cell receptor signaling and inflammation control CD8 memory differentiation.


T cell memory Signaling Inflammation Infection T cell receptor CD8 T cell CD4 T cell 



Antigen presenting cell

Bcl- or BCL

B-cell lymphoma/leukemia


Transcriptional repressor B-lymphocyte-induced maturation protein 1


B- and T-lymphocyte attenuator


Dendritic cell


Extracellular signal-regulated kinases


GA-binding protein α


Growth factor independence 1


Glycogen synthase kinase 3


Homeostatic proliferation


DNA-binding protein inhibitor 2




IκB kinase




Immunoreceptor tyrosine-based activation motif


Janus protein tyrosine kinase


c-Jun N-terminal kinase


Killer cell lectin-like receptor subfamily G member 1


Listeria monocytogenes


Linker for activation of T cells


Leukocyte-specific protein tyrosine kinase


Lymphocytic choriomeningitis virus


Lung Krüppel-like factor


Mucosa-associated lymphoid tissue lymphoma translocation protein 1


Mitogen-activated protein kinase


Myeloid cell leukemia sequence 1


Mammalian mitogen-activated protein kinase kinase kinase


Major histocompatibility complex


Memory precursor effector cells


Mammalian target of rapamycin


Nuclear factor of activated T cells


Nuclear factor κ-light-chain-enhancer of activated B cells


NF-κB-inducing kinase

NK cells

Natural killer cells


Peptide-MHC complex


Phosphoinositide 3-kinase


Protein kinase C θ


Ribosomal s6 kinase


Short-lived effector cells


SH2 domain containing leukocyte protein of 76 kDa


Serine protease inhibitor 2A


Signal transducers and activator of transcription


TGF-beta activated kinase 1


T-cell factor/lymphoid enhancer factor 1


Central memory T cell


T cell receptor


Effector memory T cell


T helper cell


Toll-like receptor


Tumor necrosis factor


Tumor necrosis factor receptor


TNF receptor-associated factor-6


X-box-binding protein 1


Zeta-chain-associated protein kinase 70



We acknowledge the University of Missouri Mission Enhancement Fund for supporting our work. We thank Karin Knudson, Cody Cunningham, and William Olson for interesting discussions and Dr. Ed Palmer for his support. We apologize to all authors we could not cite because of space restrictions.


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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  1. 1.Department of Molecular Microbiology and Immunology, School of Medicine, Center for Cellular and Molecular ImmunologyUniversity of MissouriColumbiaMOUSA

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