Cellular and Molecular Life Sciences

, Volume 67, Issue 10, pp 1619–1630 | Cite as

Crossing paths: interactions between the cell death machinery and growth factor survival signals

  • Gabriela Brumatti
  • Marika Salmanidis
  • Paul G. Ekert
Multi-author Review

Abstract

Cytokines and growth factors play a crucial role in the maintenance of haematopoietic homeostasis. They transduce signals that regulate the competing commitments of haematopoietic stem cells, quiescence or proliferation, retention of stem cell pluripotency or differentiation, and survival or demise. When the balance between these commitments and the requirements of the organisms is disturbed, particularly when it favours survival and proliferation, cancer may result. Cell death provoked by loss of growth factor signalling is regulated by the Bcl-2 family of apoptosis regulators, and thus survival messages transduced by growth factors must regulate the activity of these proteins. Many aspects of direct interactions between cytokine signalling and regulation of apoptosis remain elusive. In this review, we explore the mechanisms by which cytokines, in particular Interleukin-3 and granulocyte–macrophage colony-stimulating factor, promote cell survival and suppress apoptosis as models of how cytokine signalling and apoptotic pathways intersect.

Keywords

Cytokines Growth factors Apoptosis Haematopoiesis Bcl-2 family Tumorigenesis 

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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Gabriela Brumatti
    • 1
  • Marika Salmanidis
    • 1
  • Paul G. Ekert
    • 1
  1. 1.Children’s Cancer Centre, Murdoch Children’s Research Institute, Royal Children’s Hospital, Department of PaediatricsUniversity of MelbourneMelbourneAustralia

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