Cellular and Molecular Life Sciences

, Volume 67, Issue 10, pp 1589–1597

Mitochondrial control of caspase-dependent and -independent cell death

  • Ludivine A. Pradelli
  • Marie Bénéteau
  • Jean-Ehrland Ricci
Multi-author Review

Abstract

Mitochondria control whether a cell lives or dies. The role mitochondria play in deciding the fate of a cell was first identified in the mid-1990s, because mitochondria-enriched fractions were found to be necessary for activation of death proteases, the caspases, in a cell-free model of apoptotic cell death. Mitochondrial involvement in apoptosis was subsequently shown to be regulated by Bcl-2, a protein that was known to contribute to cancer in specific circumstances. The important role of mitochondria in promoting caspase activation has therefore been a major focus of apoptosis research; however, it is also clear that mitochondria contribute to cell death by caspase-independent mechanisms. In this review, we will highlight recent findings and discuss the mechanism underlying the mitochondrial control of apoptosis and caspase-independent cell death.

Keywords

Mitochondria Bcl-2 family Cell death Apoptosis Caspase-independent cell death Mitochondrial outer membrane permeabilization Cancer BH3 mimetics 

Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Ludivine A. Pradelli
    • 1
    • 2
  • Marie Bénéteau
    • 1
    • 2
  • Jean-Ehrland Ricci
    • 1
    • 2
    • 3
  1. 1.Inserm, U895, Centre Méditerranéen de Médecine Moléculaire (C3M)Nice Cedex 3France
  2. 2.Université de Nice-Sophia-Antipolis, Faculté de MédecineNice Cedex 2France
  3. 3.Centre Hospitalier Universitaire de Nice, Département d’Anesthésie RéanimationNice Cedex 3France

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