Cellular and Molecular Life Sciences

, Volume 66, Issue 9, pp 1507–1517

Diversity in enoyl-acyl carrier protein reductases

Review

Abstract.

The enoyl-acyl carrier protein reductase (ENR) is the last enzyme in the fatty acid elongation cycle. Unlike most enzymes in this essential pathway, ENR displays an unusual diversity among organisms. The growing interest in ENRs is mainly due to the fact that a variety of both synthetic and natural antibacterial compounds are shown to specifically target their activity. The primary anti-tuberculosis drug, isoniazid, and the broadly used antibacterial compound, triclosan, both target this enzyme. In this review, we discuss the diversity of ENRs, and their inhibitors in the light of current research progress.

Keywords.

Enoyl-acyl carrier protein reductase fatty acid biosynthesis Fatty acid synthesis II triclosan shortchain dehydrogenase reductase medium-chain dehydrogenase reductase 

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Copyright information

© Birkhäuser Verlag, Basel 2009

Authors and Affiliations

  1. 1.Departments of Microbiology, B103, Chemical and Life Sciences LaboratoryUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  2. 2.Department of BiochemistryUniversity of Illinois at Urbana-ChampaignUrbanaUSA

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