Cellular and Molecular Life Sciences

, Volume 67, Issue 4, pp 545–556 | Cite as

Platelets and viruses: an ambivalent relationship

  • Claire Flaujac
  • Siham Boukour
  • Elisabeth Cramer-Bordé
Multi-author Review


Thrombocytopenia is a frequent complication of viral infections providing evidence that interaction of platelets with viruses is an important pathophysiological phenomenon. Multiple mechanisms are involved depending on the nature of the viruses involved. These include immunological platelet destruction, inappropriate platelet activation and consumption, and impaired megakaryopoiesis. Viruses bind platelets through specific receptors and identified ligands, which lead to mutual alterations of both the platelet host and the viral aggressor. We have shown that HIV-1 viruses are internalized specifically in platelets and megakaryocytes, where they can be either sheltered, unaltered (with potential transfer of the viruses into target organs), or come in contact with platelet secretory products leading to virus destruction and facilitated platelet clearance. In this issue, we have reviewed the various pathways that platelets use in order to interact with viruses, HIV and others. This review also shows that more work is still needed to precisely identify platelet roles in viral infections, and to answer the challenge of viral safety in platelet transfusion.


Platelet Megakaryocyte Virus Thrombocytopenia Receptors Immunity Transfusion 



The authors acknowledge Dr. Karim Benhioud (Institut Gustave Roussy, Villejuif) for providing the mouse model of adenovirus infection and Miss Laurence Momeux for photographic help.


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Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Claire Flaujac
    • 1
    • 2
    • 3
  • Siham Boukour
    • 1
    • 2
    • 3
  • Elisabeth Cramer-Bordé
    • 1
    • 2
    • 3
  1. 1.Service d’Hématologie et d’ImmunologieHôpital Ambroise ParéParisFrance
  2. 2.Faculté de Médecine Paris-Ile de France- OuestUniversité de VersaillesVersaillesFrance
  3. 3.INSERM U567, Département d’hématologieInstitut CochinParisFrance

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