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Cellular and Molecular Life Sciences

, Volume 67, Issue 2, pp 239–253 | Cite as

Key factors in mTOR regulation

  • Xiaochun BaiEmail author
  • Yu JiangEmail author
Review

Abstract

Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that controls a wide range of growth-related cellular processes. In the past several years, many factors have been identified that are involved in controlling mTOR activity. Those factors in turn are regulated by diverse signaling cascades responsive to changes in intracellular and environmental conditions. The molecular connections between mTOR and its regulators form a complex signaling network that governs cellular metabolism, growth and proliferation. In this review, we discuss some key factors in mTOR regulation and mechanisms by which these factors control mTOR activity.

Keywords

mTOR TSC2 Rheb FKBP38 PRAS40 hVps34 Rag GTPases Phosphatidic acid 

Notes

Acknowledgments

The authors thank their colleagues for stimulating discussion and critical reading of this manuscript. This work was supported by NIH grants CA129821 and GM068832 to YJ.

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Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  1. 1.Department of Cell Biology, School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina
  2. 2.Department of Pharmacology and Chemical BiologyUniversity of Pittsburgh School of MedicinePittsburghUSA

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