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Cellular and Molecular Life Sciences

, Volume 67, Issue 2, pp 179–199 | Cite as

Protein transport across and into cell membranes in bacteria and archaea

  • Jijun Yuan
  • Jessica C. Zweers
  • Jan Maarten van Dijl
  • Ross E. Dalbey
Review

Abstract

In the three domains of life, the Sec, YidC/Oxa1, and Tat translocases play important roles in protein translocation across membranes and membrane protein insertion. While extensive studies have been performed on the endoplasmic reticular and Escherichia coli systems, far fewer studies have been done on archaea, other Gram-negative bacteria, and Gram-positive bacteria. Interestingly, work carried out to date has shown that there are differences in the protein transport systems in terms of the number of translocase components and, in some cases, the translocation mechanisms and energy sources that drive translocation. In this review, we will describe the different systems employed to translocate and insert proteins across or into the cytoplasmic membrane of archaea and bacteria.

Keywords

Archaea Gram-positive SecYEG Tat YidC 

Notes

Acknowledgments

This work was supported by the National Institutes of Health grant GM63862 (to R.E. D.), EU grants LSHM-CT-2006-019064 and PITN-GA-2008-215524, the transnational SysMO initiative through project BACELL SysMO, the European Science Foundation under the EUROCORES Programme EuroSCOPE, and grant 04-EScope 01-011 from the Research Council for Earth and Life Sciences of the Netherlands Organization for Scientific Research (to J.M.v.D.).

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Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  1. 1.Department of ChemistryThe Ohio State UniversityColumbusUSA
  2. 2.Department of Medical MicrobiologyUniversity Medical Center Groningen and University of GroningenGroningenThe Netherlands

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