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Cellular and Molecular Life Sciences

, Volume 66, Issue 24, pp 3831–3836 | Cite as

New insights into mineralogenic effects of vanadate

  • Vincent Laizé
  • Daniel M. Tiago
  • Manuel Aureliano
  • M. Leonor Cancela
Visions & Reflections (Minireview)

Introduction

Vanadium is a transition metal that occurs naturally in a variety of minerals and exhibits an exceptional complex chemistry in solution, e.g., several oxidation states ranging from +2 to +5, and formation of vanadium oligomers such as decameric vanadate (+5) species [1, 2, 3, 4]. Besides its metallurgical role in steel alloys, vanadium is also an ultra trace element known to participate in many biological processes and considered to be essential for living organisms [5, 6]. It accumulates in a variety of organisms ranging from microbes to vertebrates, where it modulates the activity of an array of key enzymes or participates as a cofactor in the active centre of others [1, 2, 5, 6, 7, 8, 9]. In mammals, vanadium compounds can mimic insulin action and may prevent chemical carcinogenesis, most probably through the inhibition of cellular tyrosine phosphatases and subsequent activation of signalling pathways, suggesting their use as pharmacological tools to treat human...

Keywords

Vanadium PD98059 Wortmannin Vanadium Compound ATDC5 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by CCMAR plurianual funding. DMT was the recipient of a postdoctoral fellowship (SFRH/BPD/45034/2008) from the Portuguese Science and Technology Foundation.

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Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Vincent Laizé
    • 1
  • Daniel M. Tiago
    • 1
  • Manuel Aureliano
    • 1
  • M. Leonor Cancela
    • 1
  1. 1.Centre of Marine Sciences (CCMAR)University of AlgarveFaroPortugal

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