Cellular and Molecular Life Sciences

, Volume 66, Issue 15, pp 2457–2478

The human selenoproteome: recent insights into functions and regulation


DOI: 10.1007/s00018-009-0032-4

Cite this article as:
Reeves, M.A. & Hoffmann, P.R. Cell. Mol. Life Sci. (2009) 66: 2457. doi:10.1007/s00018-009-0032-4


Selenium (Se) is a nutritional trace mineral essential for various aspects of human health that exerts its effects mainly through its incorporation into selenoproteins as the amino acid, selenocysteine. Twenty-five selenoprotein genes have been identified in humans and several selenoproteins are broadly classified as antioxidant enzymes. As progress is made on characterizing the individual members of this protein family, however, it is becoming clear that their properties and functions are quite diverse. This review summarizes recent insights into properties of individual selenoproteins such as tissue distribution, subcellular localization, and regulation of expression. Also discussed are potential roles the different selenoproteins play in human health and disease.


Selenium Selenoprotein Selenocysteine Antioxidant Redox 

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  1. 1.Department of Cell and Molecular Biology, John A. Burns School of MedicineUniversity of HawaiiHonoluluUSA

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