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Cellular and Molecular Life Sciences

, Volume 66, Issue 14, pp 2319–2328 | Cite as

Cytoskeleton–membrane interactions in membrane raft structure

  • Gurunadh R. Chichili
  • William RodgersEmail author
Review

Abstract

Cell membranes are structurally heterogeneous, composed of discrete domains with unique physical and biological properties. Membrane domains can form through a number of mechanisms involving lipid–lipid and protein–lipid interactions. One type of membrane domain is the cholesterol-dependent membrane raft. How rafts form remains a current topic in membrane biology. We review here evidence of structuring of rafts by the cortical actin cytoskeleton. This includes evidence that the actin cytoskeleton associates with rafts, and that many of the structural and functional properties of rafts require an intact actin cytoskeleton. We discuss the mechanisms of the actin-dependent raft organization, and the properties of the actin cytoskeleton in regulating raft-associated signaling events. We end with a discussion of membrane rafts and the actin cytoskeleton in T cell activation, which function synergistically to initiate the adaptive immune response.

Keywords

Membrane rafts Actin cytoskeleton Phosphatidylinositol 4 5 bisphosphate T cell signaling Src family kinases 

Notes

Acknowledgments

This work was supported by NIH grant R01 GM070001 and Oklahoma Center for the advancement of Science and Technology grants HR08-084 (WR).

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Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  1. 1.Cardiovascular Biology Research ProgramOklahoma Medical Research FoundationOklahoma CityUSA

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