Cellular and Molecular Life Sciences

, Volume 66, Issue 13, pp 2123–2134 | Cite as

Recent advances in understanding the structure and function of general transcription factor TFIID

  • Emilie Cler
  • Gabor Papai
  • Patrick Schultz
  • Irwin Davidson
Review

Abstract

The general transcription factor TFIID is a macromolecular complex comprising the TATA-binding protein (TBP) and a set of 13–14 TBP associated factors (TAFs). This review discusses biochemical, genetic and electron microscopic data acquired over the past years that provide a model for the composition, organisation and assembly of TFIID. We also revisit ideas on how TFIID is recruited to the promoters of active and possibly repressed genes. Recent observations show that recognition of acetylated and methylated histone residues by structural domains in several TAFs plays an important role. Finally, we highlight several genetic studies suggesting that TFIID is required for initiation of transcription, but not for maintaining transcription once a promoter is in an active state.

Keywords

Drosophila Yeast Electron microscopy Chromatin Acetylation Methylation 

Notes

Acknowledgments

Work in the Davidson and Schultz laboratories is supported by grants from the CNRS, the INSERM, the Association pour la Recherche contre le Cancer and the Ligue Nationale et Départementale Région Alsace contre le Cancer. ID is an ‘équipe labélisée of the Ligue Nationale contre le Cancer, the Fondation pour la Recherche Médicale (FRM), the ANR the European SPINE programme QLG-CT-00988 and European Union grant RTN-2001-00026 and integrated programme grant EuTRACC. E. Cler was supported by a fellowship from the FRM, and G. Papai from the ANR.

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Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Emilie Cler
    • 1
  • Gabor Papai
    • 1
  • Patrick Schultz
    • 1
  • Irwin Davidson
    • 1
  1. 1.Institut de Génétique et de Biologie Moléculaire et CellulaireCNRS/INSERM/ULPIllkirch CedexFrance

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