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Loss of FrmA leads to increased cell-cell adhesion and impaired multi-cellular development of Dictyostelium cells

  • H. PatelEmail author
  • V. G. Brunton
Research Article

Abstract.

Cell-cell adhesion is a critical property of all multi-cellular organisms and its correct regulation is critical during development, differentiation, tissue building and maintenance, and many immune responses. The multi-talin-like FERM domain containing protein, FrmA, is required during starvation-induced multi-cellular development of Dictyostelium cells. Loss of FrmA leads to increased cell-cell adhesion and results in impaired multi-cellular development, slug migration and fruiting bodies. Further, mixing experiments show that FrmA null cells are excluded from the apex of wild-type mounds, to which cells that normally form the organising centre known as the tip sort. These data suggest a critical role for FrmA in regulating cell-cell adhesion, multi-cellular development and, in particular, the formation of the organising centre known as the tip.

Keywords.

Adhesion development FERM migration Dictyostelium 

Supplementary material

18_2008_8527_MOESM1_ESM.pdf (354 kb)
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Copyright information

© Birkhäuser Verlag, Basel 2008

Authors and Affiliations

  1. 1.Edinburgh Cancer Research CentreThe University of EdinburghEdinburghScotland

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