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Cellular and Molecular Life Sciences

, Volume 65, Issue 21, pp 3383–3398 | Cite as

Endogenous retroviruses

Murine endogenous retroviruses
  • C. StockingEmail author
  • C. A. KozakEmail author
Multi-author Review

Abstract.

Up to 10% of the mouse genome is comprised of endogenous retrovirus (ERV) sequences, and most represent the remains of ancient germ line infections. Our knowledge of the three distinct classes of ERVs is inversely correlated with their copy number, and their characterization has benefited from the availability of divergent wild mouse species and subspecies, and from ongoing analysis of the Mus genome sequence. In contrast to human ERVs, which are nearly all extinct, active mouse ERVs can still be found in all three ERV classes. The distribution and diversity of ERVs has been shaped by host-virus interactions over the course of evolution, but ERVs have also been pivotal in shaping the mouse genome by altering host genes through insertional mutagenesis, by adding novel regulatory and coding sequences, and by their co-option by host cells as retroviral resistance genes. We review mechanisms by which an adaptive coexistence has evolved. (Part of a Multiauthor Review)

Keywords.

Virus restriction factors retroviral receptors Env-receptor interactions murine ERV classification 

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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Heinrich-Pette-InstituteHamburgGermany
  2. 2.Laboratory of Molecular MicrobiologyNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesda, MarylandUSA

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