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Cellular and Molecular Life Sciences

, Volume 65, Issue 18, pp 2814–2832 | Cite as

Membrane traffic in the secretory pathway

Membrane fusion: SNAREs and regulation
  • J. Malsam
  • S. Kreye
  • T. H. SöllnerEmail author
Multi-author Review

Abstract.

SNARE (SNAP receptor) proteins drive intracellular membrane fusion and contribute specificity to membrane trafficking. The formation of SNAREpins between membranes is spatially and temporally controlled by a network of sequentially acting accessory components. These regulators add an additional layer of specificity, arrest SNAREpin intermediates, lower the energy required for fusion, and couple membrane fusion to triggering signals. The functional activity of some of these regulators determines the plasticity of regulated exocytosis. (Part of a Multi-author Review)

Keywords.

Exocytosis fusion vesicle tether synaptotagmin SM protein Munc13 complexin 

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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Biochemistry CenterUniversity HeidelbergHeidelbergGermany

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