Cellular and Molecular Life Sciences

, Volume 65, Issue 19, pp 2953–2956

Protein assemblies with palindromic structure motifs

Visions & Reflections (Minireview)

DOI: 10.1007/s00018-008-8265-1

Cite this article as:
Pinotsis, N. & Wilmanns, M. Cell. Mol. Life Sci. (2008) 65: 2953. doi:10.1007/s00018-008-8265-1


Symmetric DNA sequence motifs allow the formation of palindromic protein/DNA complexes. Although symmetric protein sequence motifs are less common, recent structural discoveries have unraveled a few protein/protein complexes with palindromic symmetry. Remarkably, symmetric protein/protein complexes can be generated either by adjacent or remote sequence motifs, which may be repeated or inverted. This contribution reflects and comments on recent findings of palindromic protein/protein complexes.


Protein structure palindromic symmetry SH3 domain titin muscle 


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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.EMBL HamburgHamburgGermany
  2. 2.Section of Structural BiologyInstitute of Cancer Research, Chester Beatty LaboratoriesLondonUnited Kingdom

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