Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
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- Bellone, C., Lüscher, C. & Mameli, M. Cell. Mol. Life Sci. (2008) 65: 2913. doi:10.1007/s00018-008-8263-3
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Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.