Cellular and Molecular Life Sciences

, Volume 65, Issue 18, pp 2913–2923 | Cite as

Mechanisms of synaptic depression triggered by metabotropic glutamate receptors



Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.


Long-term depression synaptic transmission metabotropic glutamate receptors AMPA receptors 


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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Dept. of Basic Neurosciences, Medical FacultyUniversity of GenevaGenevaSwitzerland
  2. 2.Clinic of Neurology, Dept. of Clinical NeurosciencesGeneva University HospitalGenevaSwitzerland

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