Cellular and Molecular Life Sciences

, Volume 65, Issue 22, pp 3564–3591

Cell penetrating peptide inhibitors of Nuclear Factor-kappa B

Review

DOI: 10.1007/s00018-008-8222-z

Cite this article as:
Orange, J.S. & May, M.J. Cell. Mol. Life Sci. (2008) 65: 3564. doi:10.1007/s00018-008-8222-z

Abstract.

The nuclear factor kappa B (NF-κB) transcription factors are activated by a range of stimuli including pro-inflammatory cytokines. Active NF-κB regulates the expression of genes involved in inflammation and cell survival and aberrant NF-κB activity plays pathological roles in certain types of cancer and diseases characterized by chronic inflammation. NF-κB signaling is an attractive target for the development of novel anti-inflammatory or anti-cancer drugs and we discuss here how the method of peptide transduction has been used to specifically target NF-κB. Peptide transduction relies on the ability of certain small cell-penetrating peptides (CPPs) to enter cells, and a panel of CPP-linked inhibitors (CPP-Is) has been developed to directly inhibit NF-κB signaling. Remarkably, several of these NF-κB-targeting CPP-Is are effective in vivo and therefore offer exciting potential in the clinical setting.

Keywords.

Nuclear Factor kappa B I kappa B Kinase cell penetrating peptide peptide transduction signal transduction 

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Department of PediatricsUniversity of Pennsylvania School of Medicine, The Children’s Hospital of Philadelphia 3615 Civic Center Blvd., ARC 1016HPhiladelphiaUSA
  2. 2.Department of Animal Biology and The Mari Lowe Center for Comparative OncologyUniversity of Pennsylvania School of Veterinary MedicinePhiladelphiaUSA

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