Cellular and Molecular Life Sciences

, Volume 65, Issue 19, pp 3019–3027

Multi-layered regulation of intestinal antimicrobial defense

Review

DOI: 10.1007/s00018-008-8182-3

Cite this article as:
Mukherjee, S., Vaishnava, S. & Hooper, L.V. Cell. Mol. Life Sci. (2008) 65: 3019. doi:10.1007/s00018-008-8182-3

Abstract.

The gastrointestinal tract of mammals is heavily colonized with a complex and dynamic microbial community. To cope with this complex microbial challenge, multiple epithelial lineages, such as enterocytes and Paneth cells, elaborate a diverse repertoire of protein antibiotics. The gut antimicrobial arsenal encompasses multiple protein families, including defensins, cathelicidins, and C-type lectins. These antimicrobial peptides and proteins play a key role in protecting the host against pathogen challenge, and likely also function to limit invasion of indigenous microbes. It is becoming increasingly apparent that expression of mucosal antimicrobial defenses is tightly controlled. This occurs at multiple levels, including transcriptional regulation in response to bacterial cues, post-translational proteolytic processing, and bacterial regulation of Paneth cell degranulation. Impaired antimicrobial peptide expression has also been implicated in inflammatory bowel disease, underscoring the essential role of antimicrobial defenses in maintaining intestinal homeostasis.

Keywords.

Paneth cell defensin cathelicidin C-type lectin inflammatory bowel disease 

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Department of ImmunologyThe University of Texas Southwestern Medical Center at DallasDallasUSA
  2. 2.Department of MicrobiologyThe University of Texas Southwestern Medical Center at DallasDallasUSA

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