Cellular and Molecular Life Sciences

, Volume 65, Issue 19, pp 3058–3073 | Cite as

Structure and dynamic regulation of Src-family kinases

  • J. R. Engen
  • T. E. Wales
  • J. M. Hochrein
  • M. A. MeynIII
  • S. Banu Ozkan
  • I. Bahar
  • T. E. Smithgall
Review

Abstract.

Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.

Keywords.

Src-family kinases SH3 domain SH2 domain hydrogen exchange mass spectrometry Gaussian Network Model 

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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • J. R. Engen
    • 1
  • T. E. Wales
    • 1
  • J. M. Hochrein
    • 2
  • M. A. MeynIII
    • 3
  • S. Banu Ozkan
    • 4
  • I. Bahar
    • 5
  • T. E. Smithgall
    • 3
  1. 1.Department of Chemistry and Chemical Biology and the Barnett Institute of Chemical and Biological AnalysisNortheastern UniversityBostonUSA
  2. 2.Materials Reliability DepartmentSandia National LaboratoriesAlbuquerqueUSA
  3. 3.Department of Microbiology and Molecular GeneticsUniversity of Pittsburgh School of MedicinePittsburghUSA
  4. 4.Center for Biological Physics, Department of PhysicsArizona State UniversityTempeUSA
  5. 5.Department of Computational BiologyUniversity of Pittsburgh School of MedicinePittsburghUSA

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