p63 in epithelial development

  • E. Candi
  • R. Cipollone
  • P. Rivetti di Val Cervo
  • S. Gonfloni
  • G. Melino
  • R. Knight
Visions & Reflections(minireview)

Abstract.

The epidermis, the outer layer of the skin composed of keratinocytes, is a stratified epithelium that functions as a barrier to protect the organism from dehydration and external insults. The epidermis develops following the action of the transcription factor p63, amember of the p53 family of transcription factors. The Trp63 gene contains two promoters driving the production of distinct proteins, one with an N-terminal transactivation domain (TAp63) and one without (ΔNp63), although their relative contribution to epidermal development is not clearly established. Trp63 mutations are involved in the pathogenesis of several human diseases, phenotypically characterized by ectodermal dysplasia. In this review, we summarize the current advances that have been made in understanding the role of p63 in epidermal morphogenesis.

Keywords.

p63 epidermis cornification skin development Itch ubiquitin E3 ligase 

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • E. Candi
    • 1
  • R. Cipollone
    • 1
  • P. Rivetti di Val Cervo
    • 1
  • S. Gonfloni
    • 2
  • G. Melino
    • 1
    • 3
  • R. Knight
    • 3
  1. 1.Biochemistry Laboratory IDI-IRCCS and University of Rome ‘Tor Vergata’RomeItaly
  2. 2.Department of BiologyUniversity of Rome ‘Tor Vergata’RomeItaly
  3. 3.Medical Research Council, Toxicology UnitLeicester UniversityLeicesterUK

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