Cellular and Molecular Life Sciences

, Volume 65, Issue 16, pp 2528–2540

Purinergic regulation of neutrophil chemotaxis



Chemotaxis allows polymorphonuclear neutrophils (PMN) to rapidly reach infected and inflamed sites. However, excessive influx of PMN damages host tissues. Better knowledge of the mechanisms that control PMN chemotaxis may lead to improved treatments of inflammatory diseases. Recent findings suggest that ATP and adenosine are involved in PMN chemotaxis. Therefore, these purinergic signaling processes may be suitable targets for novel therapeutic approaches to ameliorate host tissue damage.


Neutrophils inflammation chemotaxis puringeric receptors tissue damage 


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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Department of SurgeryBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA

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