Cellular and Molecular Life Sciences

, Volume 65, Issue 15, pp 2360–2371

UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

Open Access

DOI: 10.1007/s00018-008-8072-8

Cite this article as:
Schuberth, C. & Buchberger, A. Cell. Mol. Life Sci. (2008) 65: 2360. doi:10.1007/s00018-008-8072-8


The highly conserved AAA ATPase Cdc48/p97 acts on ubiquitylated substrate proteins in cellular processes as diverse as the fusion of homotypic membranes and the degradation of misfolded proteins. The ‘Ubiquitin regulatory X’ (UBX) domain-containing proteins constitute the so far largest family of Cdc48/p97 cofactors. UBX proteins are involved in substrate recruitment to Cdc48/p97 and in the temporal and spatial regulation of its activity. In combination with UBX-like proteins and other cofactors, they can assemble into a large variety of Cdc48/p97-cofactor complexes possessing distinct cellular functions. This review gives an overview of the different subfamilies of UBX proteins and their functions, and discusses general principles of Cdc48/p97 regulation by these cofactors.


AAA ATPase valosin-containing protein (VCP) ubiquitin/proteasome system protein degradation UBA domain ubiquitin-like fold 
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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Cell Biology and Biophysics UnitEMBL HeidelbergHeidelbergGermany
  2. 2.Department of Molecular Cell BiologyMax Planck Institute of BiochemistryMartinsriedGermany

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