Cellular and Molecular Life Sciences

, Volume 65, Issue 19, pp 2964–2978 | Cite as

TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme

  • L. Verstrepen
  • T. Bekaert
  • T.-L. Chau
  • J. Tavernier
  • A. Chariot
  • R. Beyaert
Review

Abstract.

Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and interleukin-1 (IL-1R) play an important role in innate immunity by regulating the activity of distinct transcription factors such as nuclear factor-κB (NF-κB). TLR, IL-1R and TNF-R signaling to NF-κB converge on a common IκB kinase complex that phosphorylates the NF-κB inhibitory protein IκBα. However, upstream signaling components are in large part receptor-specific. Nevertheless, the principles of signaling are similar, involving the recruitment of specific adaptor proteins and the activation of kinase cascades in which protein-protein interactions are controlled by poly-ubiquitination. In this review, we will discuss our current knowledge of NF-κB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways.

Keywords.

Toll-like receptor 4 interleukin-1 tumor necrosis factor NF-κB signal transduction 

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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • L. Verstrepen
    • 1
    • 2
  • T. Bekaert
    • 1
    • 2
  • T.-L. Chau
    • 3
  • J. Tavernier
    • 4
    • 5
  • A. Chariot
    • 3
  • R. Beyaert
    • 1
    • 2
  1. 1.Department of Molecular BiologyGhent UniversityGhentBelgium
  2. 2.Department for Molecular Biomedical ResearchUnit of Molecular Signal Transduction in InflammationGhentBelgium
  3. 3.Interdisciplinary Cluster for Applied Genoproteomics, Unit of Medical Chemistry and Signal TransductionUniversity of LiegeLiègeBelgium
  4. 4.Department of Medical Protein Research, VIBGhentBelgium
  5. 5.Department of Biochemistry, Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium

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