Cellular and Molecular Life Sciences

, Volume 65, Issue 14, pp 2191–2214

G protein βγ subunits: Central mediators of G protein-coupled receptor signaling



G protein βγ subunits are central participants in G protein-coupled receptor signaling pathways. They interact with receptors, G protein α subunits and downstream targets to coordinate multiple, different GPCR functions. Much is known about the biology of Gβγ subunits but mysteries remain. Here, we will review what is known about general aspects of structure and function of Gβγ as well as discuss emerging mechanisms for regulation of Gβγ signaling. Recent data suggest that Gβγ is a potential therapeutic drug target. Thus, a thorough understanding of the molecular and physiological functions of Gβγ has significant implications.


G protein-coupled receptor G protein βγ subunits signal transduction protein-protein interactions 


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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Department of Pharmacology and PhysiologyUniversity of Rochester School of Medicine and DentistryRochesterUnited States

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