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Cellular and Molecular Life Sciences

, Volume 65, Issue 16, pp 2484–2492 | Cite as

The specificity of binding of glycoprotein hormones to their receptors

  • G. Caltabiano
  • M. Campillo
  • A. De Leener
  • G. Smits
  • G. Vassart
  • S. Costagliola
  • L. PardoEmail author
Review

Abstract.

The glycoprotein hormone receptor family is peculiar because, in contrast to other G protein-coupled receptors, a large N-terminal extracellular ectodomain is responsible for hormone recognition. Hormone-receptor pairs have evolved in such a manner that a limited number of positions both at the ‘seat-belt’ domain of the hormone and the leucine-rich repeats of the receptor, play attractive and repulsive interactions for binding and specificity, respectively. Surprisingly, the constitutive activity of the receptor, mostly modulated by highly conserved amino acids within the heptahelical domain of the receptor (i.e., outside the hormone binding region), also regulates effectiveness of hormone recognition by the extracellular part. In this review we analyze, at the molecular level, these important discriminating determinants for selective binding of glycoprotein hormones to their receptors, as well as natural mutations, observed in patients with gestational hyperthyroidism or ovarian hyperstimulation syndrome, that modify the selectivity of binding.

Keywords.

Glycoprotein hormone receptors hormone specificity ovarian hyperstimulation syndrome gestational hyperthyroidism 

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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • G. Caltabiano
    • 1
  • M. Campillo
    • 1
  • A. De Leener
    • 2
  • G. Smits
    • 2
  • G. Vassart
    • 2
  • S. Costagliola
    • 2
  • L. Pardo
    • 1
    Email author
  1. 1.Laboratori de Medicina Computacional, Unitat de Bioestadistica, Facultat de MedicinaUniversitat Autonoma de BarcelonaBellaterra, BarcelonaSpain
  2. 2.Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM)Université Libre de BruxellesBruxellesBelgium

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