Cellular and Molecular Life Sciences

, Volume 65, Issue 11, pp 1706–1715 | Cite as

Heparanase involvement in physiology and disease

  • N. J. NasserEmail author


Heparanase is an endoglycosidase that degrades heparan sulfate on the cell surface and extracellular matrix. The physiological functions of heparanase include heparan sulfate turnover, embryo development, hair growth, and wound healing. Heparanase is implicated in a variety of pathologies, such as tumor growth, angiogenesis, metastasis, inflammation, and glomerular diseases. Heparanase overexpression in a variety of malignant tumors suggests that it could be a target for anti-cancer therapy.


Cancer progression extracellular matrix heparin heparanase angiogenesis alternative splicing metastasis hypoxia 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Department of OncologyShaare Zedek Medical CenterJerusalemIsrael

Personalised recommendations