Cellular and Molecular Life Sciences

, Volume 65, Issue 9, pp 1361–1377

NOD-like receptors: Ancient sentinels of the innate immune system



NOD-like receptors (NLRs) comprise a family of cytosolic proteins that have been implicated as ancient cellular sentinels mediating protective immune responses elicited by intracellular pathogens or endogenous danger signals. Genetic variants in NLR genes have been associated with complex chronic inflammatory barrier diseases (e.g. Crohn disease, bronchial asthma). In this review, we focus on the molecular pathophysiology of NLRs in the context of chronic inflammatory diseases and pinpoint recent advances in the evolutionary understanding of NLR biology. We propose that the field of NLRs may serve as a prototype for how a comprehensive understanding of an element of the immunological barrier will eventually lead to the development of targeted diagnostic, therapeutic and/or preventive strategies.


Innate immunity Crohn disease epithelial barrier inflammation NF-κB caspases 


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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • P. Rosenstiel
    • 1
  • G. Jacobs
    • 1
  • A. Till
    • 1
  • S. Schreiber
    • 1
    • 2
  1. 1.Department of Cell Biology and Marine Medicine, Institute for Clinical Molecular BiologyUniversity Hospital Schleswig-Holstein Campus KielKielGermany
  2. 2.First Department of MedicineUniversity Hospital Schleswig-Holstein Campus KielKielGermany

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