Cellular and Molecular Life Sciences

, Volume 65, Issue 7–8, pp 1133–1149

The magic of the hypoxia-signaling cascade


DOI: 10.1007/s00018-008-7472-0

Cite this article as:
Benizri, E., Ginouvès, A. & Berra, E. Cell. Mol. Life Sci. (2008) 65: 1133. doi:10.1007/s00018-008-7472-0


All organisms respond to changes in their environment by activating complex signaling cascades. The “hypoxia-signaling cascade” is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.


Oxygen homeostasis hypoxia HIF signaling physiopathology therapy 

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.ISDBC, CNRS UMR 6543, University of Nice, Centre Antoine LacassagneNiceFrance
  2. 2.Cell Biology and Stem Cells Unit, CICbioGUNEDerioSpain

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