Cellular and Molecular Life Sciences

, Volume 68, Issue 6, pp 923–929

Fine-tuning of cell signaling by glypicans

Visions & Reflections (Minireview)

DOI: 10.1007/s00018-007-7471-6

Cite this article as:
Fico, A., Maina, F. & Dono, R. Cell. Mol. Life Sci. (2011) 68: 923. doi:10.1007/s00018-007-7471-6


Signaling peptides of the extracellular environment regulate cell biological processes underlying embryonic development, tissue homeostasis, and pathophysiology. The heparan sulphate proteoglycans, glypicans, have evolved as essential modulators of key regulatory proteins such as Wnt, Bmp, Fgf, and Shh. By acting on signal spreading and receptor activation, glypicans can control signal read-out and fate in targeted cells. Genetic and embryological studies have highlighted that glypicans act in a temporal and spatially regulated manner to modulate distinct cellular events. However, alterations of glypican function underlie human congenital malformations and cancer. Recent reports are starting to reveal their mechanism of action and how they can ensure tight modulation of cell signaling.


Glypican HSPG Cell signaling Signaling cell-based therapy modulator Morphogen Human disorder Cancer Stem cells 

Copyright information

© Springer Basel AG 2007

Authors and Affiliations

  1. 1.Developmental Biology Institute of Marseille-Luminy (IBDML)CNRS UMR 6216, Inserm, Université de la MéditerrannéeMarseille Cedex 09France

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