Molecular and Cellular Basis of Regeneration and Tissue Repair

The logic and regulation of cell cycle exit and reentry
  • D. Pajalunga
  • A. Mazzola
  • A. Franchitto
  • E. Puggioni
  • M. Crescenzi
Multi-author Review

Abstract.

Tissue repair and regeneration are very complex biological events, whose successful attainment requires far more than mere cell division. However, almost unavoidably they entail cell proliferation as a fundamental premise. Full regeneration or repair cannot be achieved without replacing cells lost to disease or injury, replacement that can only take place via proliferation of surviving cells. This review endeavors to outline the molecular bases of exit from and reentry into the cell cycle. In recent years, the decision to proliferate or not has been seen as mostly the concern of cyclins and cyclin-dependent kinases. This account tries to show that cell cycle inhibitors are as important as the positive regulators in the making of this decision. Finally, the authors wish to suggest that the molecular knowledge of the cell cycle can be harnessed to the benefit of many aspects of regenerative medicine. (Part of Multi-author Review)

Keywords.

Cell cycle quiescence terminal differentiation proliferative senescence cyclins cyclin-dependent kinase inhibitors 

Copyright information

© Birkhaueser 2007

Authors and Affiliations

  • D. Pajalunga
    • 1
  • A. Mazzola
    • 1
  • A. Franchitto
    • 1
  • E. Puggioni
    • 1
  • M. Crescenzi
    • 1
  1. 1.Dept. of Environment and Primary PreventionIstituto Superiore di Sanità — Viale Regina Elena, 299RomaItaly

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