Cellular and Molecular Life Sciences

, Volume 64, Issue 18, pp 2413–2421 | Cite as

Aquaporins with selectivity for unconventional permeants

  • B. Wu
  • E. Beitz


The aquaporin protein family generally seems to be designed for the selective passage of water or glycerol. Charged molecules, metal ions and even protons are strictly excluded. Recently, particular aquaporin isoforms were reported to conduct unconventional permeants, i.e., the unpolar gases carbon dioxide and nitric oxide, the polar gas ammonia, the oxidative oxygen species hydrogen peroxide, and the metalloids antimonite, arsenite and silicic acid. Here, we summarize the available data on permeability properties and physiological settings of these aquaporins and we analyze which structural features might be connected to permeability for non-water, non-glycerol solutes.


Aquaporin aquaglyceroporin carbon dioxide nitric oxide hydrogen peroxide ammonia arsenite silicon 


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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.Department of Pharmaceutical ChemistryUniversity of KielKielGermany

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