The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins

  • M. ŠtrosEmail author
  • D. Launholt
  • K. D. GrasserEmail author


The HMG-box domain of ~75 amino acid residues was originally identified as the domain that mediates the DNA-binding of chromatin-associated high-mobility group (HMG) proteins of the HMGB type. In the last few years, HMG-box domains have been found in various DNA-binding proteins including transcription factors and subunits of chromatin-remodeling complexes. HMG-box domains mediate either non-sequence-specific (e.g., HMGB-type proteins) or sequence-specific (e.g., transcription factors) DNA binding. Both types of HMG-box domains bind non-B-type DNA structures (bent, kinked and unwound) with high affinity. In addition, HMG-box domains are involved in a variety of protein-protein interactions. Here, we have examined the human and plant genomes for genes encoding HMG-box domains. Compared to plants, human cells contain a larger variety of HMG-box proteins. Whereas in humans transcription factors are the most divergent group of HMG-box proteins, in plants the chromosomal HMGB-type proteins are most variable.


High-mobility group (HMG) protein DNA binding chromatin architectural factor transcription factor genomic stability human and plant genome 

Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech RepublicInstitute of BiophysicsBrnoCzech Republic
  2. 2.Department of Life SciencesAalborg UniversityAalborgDenmark

Personalised recommendations