Cellular and molecular pathogenesis of type 1A diabetes



Type 1A diabetes is an organ-specific autoimmune disease resulting from destruction of insulin-producing pancreatic β-cells. The main susceptibility genes code for polymorphic HLA molecules and in particular alleles of class II MHC genes (DR, DQ and DP). Polymorphisms of individual genes outside the MHC also contribute to diabetes risk but recent evidence suggests that there are additional non-HLA genes determining susceptibility linked to the MHC. It is now possible using genetic and autoantibody assays to predict the development of type 1A diabetes in the majority of individuals, and trials of diabetes prevention are underway.


T1AD MHC pathogenesis autoantibody β-cell polyendocrinopathy polygenic oligogenic 

Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.Barbara Davis Center for Childhood DiabetesUniversity of Colorado, Health sciences CenterAuroraUSA
  2. 2.Pathology Department, Salmaniya Medical ComplexMinistry of HealthManamaKingdom of Bahrain

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