Cellular and Molecular Life Sciences

, Volume 64, Issue 5, pp 581–588 | Cite as

Nibbling within the nucleus: turnover of nuclear contents

  • D. Mijaljica
  • M. Prescott
  • R. J. Devenish


As the site of gene expression and regulation, the nucleus is the control center of the cell. It might be thought that degradation of nuclear contents is strictly ‘off-limits,’ given the importance of the genetic information contained within the nucleus, but it has recently been reported that partial degradation of the nucleus may occur in yeast. Here we summarize the evidence for the degradation and quality control of proteins found with the nucleus and its compartments, and of nucleic acids that may occur under certain specific conditions. Only under certain special conditions such as differentiation of the lens are the entire nuclear contents degraded.


Autophagy degradation exosome nucleoporin nuclear compartment nucleus piecemeal microautophagy protein quality control 


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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Biology, and the ARC Centre of Excellence in Structural and Functional Microbial GenomicsMonash UniversityAustralia

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